Faculty

Faculty Directory
Link Email Current Research Department
Andrea Amalfitano
Andrea Amalfitano, Director Feasibility of gene transfer to treat several diseases, both genetic and non-genetic, and to eventually translate that knowledge into the clinical realm-- studying a variety of disease models Clinical and Translation Science and Microbiology and Molecular Genetics

David N. Arnosti

David N. Arnosti, Prof Eukaryotic gene regulation, transcriptional activation, and repression in Drosophila; function of retinoblastoma tumor suppressor genes in development. Biochemistry and Molecular Biology
Cindy Arvidson
Cindy Arvidson, Assoc Prof Infections with the sexually transmitted pathogen, Neisseria gonorrhoeae (GC, gonococcus) Microbiology and Molecular Genetics
Bill Atchison
Bill Atchison, Prof Understanding the basis of cellular neurotoxicity especially at synapses. Pharmacology and Toxicology
Barbara P. Atshaves Barbara P. Atshaves, Asst Prof Lipid metabolism and chronic disease related to obesity, protein-lipid interactions regulating fat storage in adipocytes, and the role of nutraceuticals in the prevention of obesity and diabetes. Biochemistry and Molecular Biology
Christoph Benning Christoph Benning, Prof Biosynthesis of lipids in photosynthetic membranes, lipid trafficking phenomena involving chloroplasts, engineering of crops and algae for biodiesel production. Biochemistry and Molecular Biology
Federica Brandizzi
Federica Brandizzi, Prof How secretory molecules are packaged and which mechanisms regulate the shipment of compounds to the final destination. The mechanisms that lead to the establishment and maintenance of organelles of the secretory pathway. Plant Research Lab
Zachary F. Burton Zachary F. Burton, Prof Mechanism of elongation by multi-subunit RNA polymerases; RNA polymerase-drug interactions; RNA polymerase fidelity; RNA polymerase sliding on nucleic acids; molecular dynamics of RNA polymerase ternary elongation complexes. Biochemistry and Molecular Biology
Christina Chan Christina Chan, Prof System biology approaches and tissue engineering platforms, reconstructing signaling and gene regulatory networks; understanding how fatty acids are involved in the development of Alzheimer's disease. Biochemistry and Molecular Biology

Ron Chanlder, Asst Prof Integrated role of chromatin remodeling, epigenetics, and inflammatory signaling pathways in female reproductive tract homeostasis and inflammation-associated gynecologic cancer    Obstetrics Gynecology & Reproductive Bio
Tim Collier
Tim Collier, Prof, Brophy Chair Utilizes primary cell culture, rat and nonhuman primate models to study mechanisms of central nervous system aging, neurodegenerative diseases and the relationship between the two.  Current work emphasizes etiology and experimental therapeutics related to Parkinson’s disease. Current projects include collaborations in adult stem cell biology, neurobiology of aging, neural growth factor gene therapy, and re-purposing drugs for Parkinson’s disease.  Translation Science and Molecular Medicine
Susan Conrad
Susan Conrad, Prof Mechanisms by which estrogen and antiestrogens regulate the cell cycle in human breast cancer cells. Microbiology and Molecular Genetics

S. Counts

Scott Counts, Prof Molecular pathogenic mechanisms of selective neuronal vulnerability in AD. Specific topics of interest include gene regulation within vulnerable projection neurons of cholinergic basal forebrain, noradrenergic locus coeruleus, and glutamatergic medial temporal lobe circuits, differential gene regulation in familial and sporadic AD, mechanisms of neurogenetic protection during AD progression, and the discovery of potential cerebrospinal fluid AD biomarkers. Translational Science and Molecular Medicine
Paul Coussens
Paul Coussens, Prof Molecular pathogenesis laboratory focuses on the pathogenesis of Mycobacteria. Animal Science
Brad Day
Brad Day, Assoc Prof Molecular-genetics of innate immunity in plants. Plant Pathology
Dean DellaPenna
Dean DellaPenna, Prof Biochemical genomics, quantitative genetics and genome wide association mapping of dietary micronutrients in plants. Genomics of medicinal plant metabolism. Synthesis and function of lipid soluble antioxidants in plants. Biochemistry and Molecular Biology
Jerry Dodgson
Jerry Dodgson, Prof Development and use of genomics in agriculturally important species, principally chickens Microbiology and Molecular Genetics
Daniel Ducat Daniel Ducat, Asst Prof Molecular and synthetic biology approaches for the study of cyanobacterial core metabolism and redirection of photosynthetic pathways for the production of 'green' fuels and commodity products; mixed cyanobacteria-heterotroph microbial consortia. Biochemistry and Molecular Biology

Y. Dufour

Yann Dufour, Asst Prof Elemental rules that govern emergent group behaviors leading to the successful establishment of bacterial communities inside a host or in open environments. We are particularly interested in the relationships between bacterial chemotaxis, cell-to-cell communication, and the early stage of biofilm formation. Microbiology and Molecular Genetics
Susan Ewart
Susan Ewart, Prof Mechanisms of allergic and airway diseases in humans and animal models--identifying genetic, epigenetic, and environmental risk factors for asthma and related allergies. Large Animal Clinical Sciences
Eva Farre, Prof Our goal is to understand how circadian clocks work and why they play such a key role in growth and development. We study the regulation and role of circadian rhythms in plants and alga.  Plant Biology
Asgi Fazleabas
Asgi T. Fazleabas, Prof Understanding the critical cellular events that define synchrony between the developing embryo and the maternal uterus in a species that is phylogenetically related to humans will be paramount in improving the success of assisted reproductive therapies. Obstetrics Gynecology and Reproductive Biology
Michael Feig
Michael Feig, Prof Computational modeling of structure and dynamics of proteins and nucleic acids; development of implicit solvent methodologies; multiresolution modeling of supramolecular assemblies. Biochemistry and Molecular Biology
Shelagh M Ferguson-Miller Shelagh M. Ferguson-Miller, Prof Mechanism and regulation of energy transduction in mitochrondria and bacteria; kinetics, mechanics, and protein chemistry of electron transfer and proton transfer in cytochrome c oxidase. Biochemistry and Molecular Biology
Michele Fluck
Michele Fluck, Prof Polyoma virus, a mouse tumor virus, as a model to study the interactions of a virus with its host cells. Microbiology and Molecular Genetics
Dennis Fulbright
Dennis Fulbright, Prof Root rot pathogens such as Phytophthora and Macrophomina; needle cast pathogens of conifers such as Rhabdocline and Stigmina; chestnut blight caused by Cryphonectria parasitica; and, rot of chestnuts caused by bacteria, yeast, and fungi. Plant Soil and Microbial Sciences
John Fyfe
John Fyfe, Assoc Prof Spontaneously occurring genetic disease in veterinary species, primarily dogs and cats. Results of these studies reveal aspects of gene expression, protein function, and comparative medicine and give us the means to control genetic disorders in populations where they arise. Microbiology and Molecular Genetics
James Galligan
James Galligan, Prof “Purinergic neurotransmission in the intestine”, “Neural control of arteries and veins in hypertension”, “SERT KO rats are a model of sex specific visceral pain”. Pharmacology and Toxicology
Kathleen Gallo
Kathleen Gallo, Prof The role of SPRK and of other novel protein kinases in mammalian signal transduction and cancer. Physiology and Biochemistry and Molecular Biology
Patricia Ganey
Patricia Ganey, Prof Understanding mechanisms by which inflammation modulates responses to chemicals. Of particular interest are chemicals, including drugs, that damage liver. Pharmacology and Toxicology
James Geiger
James Geiger, Assoc Prof The major focus of our research is to elucidate the structures of biologically important proteins, enzymes, enzyme/substrate, protein/ligand and protein/nucleic acid complexes. Chemistry
Raymond Hammerschmidt
Raymond Hammerschmidt, Prof Physiology and biochemistry of resistance and disease; induced resistance. Plant Soil and Microbial Sciences
Sandra Haslam
Sandra Haslam, Prof Endocrinology of normal breast growth and differentiation; steroid hormone- and growth factor-mediated growth control of normal breast cells Physiology
Robert Hausinger
Robert P. Hausinger, Prof Mechanism of enzyme action; structure-function studies of enzymes; incorporation of nickel in bacterial urease; biodegradation of sulfonate compounds; DNA repair; microbial physiology. Biochemistry and Molecular Biology
Shen Yang He
Sheng Yang He, Prof

Bacterial effector proteins: a central role in promoting disease susceptibility. Plant stomata: the immune function against human and plant pathogens.

Plant Research Laboratory
Eric Hegg
Eric L. Hegg, Assoc Prof Biosynthesis, transport, and regulation of heme and other metal cofactors; biodiversity and assembly of novel H2-generating enzymes; metabolism and water transport. Biochemistry and Molecular Biology
R. William Henry
R. William Henry, Assoc Chair, Assoc Prof Transcriptional regulation in eukaryotes; functions and architecture of basal transcription machinery; molecular determination of RNA polymerase specificity.q Biochemistry and Molecular Biology
Susanne Hoffmann-Benning Susanne Hoffmann-Benning, Asst Prof Plant Biochemistry; phloem-mediated mechanisms of plant growth and development; identification of factors which regulate plant growth through changes in cell wall and cuticle biosynthesis. Biochemistry and Molecular Biology
Charles G. Hoogstraten Charles G. Hoogstraten, Assoc Prof Biophysical studies of RNA catalysis and RNA-protein interactions; macromolecular NMR and pulsed EPR methods and applications; mechanisms and regulation of eukaryotic mRNA splicing. Biochemistry and Molecular Biology

Gregg A. Howe

Gregg A. Howe, Prof Regulation of plant defense responses; biochemistry of jasmonic acid biosynthesis; plant-insect interactions. Biochemistry and Molecular Biology
Jianping Hu, Assoc Prof Our laboratory aims to dissect machineries and signaling pathways that control organelle biogenesis and function, with a focus on plant peroxisomes and mitochondria. We employ a combination of molecular genetic, cell biological, biochemical, genomic, and proteomic approaches, using Arabidopsis as a model system and focusing on plant-specific aspects. Plant Research Laboratory

Jae-Wook Jeong, Prof Normal endometrial function requires a balance of progesterone (P4) and estrogen (E2) effects.

Obstetrics, Gynecology and
Reproductive Biology
 

Cindy Jordan
Cindy Jordan, Prof We are interested in hormonal modulation of the developing and adult nervous system that leads to changes in behavior. Steroid hormones such as testosterone can alter the survival and differentiation of glia, neurons and target tissues such as muscle. Neuroscience
Jon M. Kaguni Jon M. Kaguni, Prof Mechanisms of DNA replication and its regulation in Escherichia coli; nucleic acid-protein interactions. Biochemistry and Molecular Biology
Norb Kaminski
Norb Kaminski, Prof Elucidation of the molecular mechanisms for impairment of signal transduction cascades and gene expression during lymphocyte activation by drugs and chemicals; mechanism for immune modulation by cannabinoid compounds Pharmacology and Toxicology
Nicholas M. Kanaan
Nicholas M. Kanaan, Prof

Molecular mechanisms underlying degenerative diseases such as Alzheimer’s disease and Parkinson’s disease and exploring therapeutic strategies

Cell and Molecular Biology
Donna Koslowsky
Donna Koslowsky, Assoc Prof Mechanisms involved in the regulation of mitochondrial gene expression. Microbiology and Molecular Genetics

Arjun Krishnan

Arjun Krishnan, Prof The Krishnan lab develops and applies genomics/computational approaches to find mechanistic explanations for how our genome relates to health and disease.
We use statistics and machine learning in combination with large-scale data to build genome-scale models and predictions about the genetic basis of biomedical phenomena, especially in an age-, sex-, and tissue-specific manner. We work in synergy with experimental/clinical researchers to motivate our methods and put our computational models/predictions to test in human and model systems.
For more information, go to: https://www.arjun-krishnan.net/join
Biochemistry and Molecular Biology
Lee R. Kroos  Lee R. Kroos, Prof Signaling and gene regulatory mechanisms during bacterial development; intramembrane proteases of Bacillus subtilis; the network governing sporulation during Myxococcus xanthus fruiting body formation. Biochemistry and Molecular Biology
Min-Hao Kuo  Min-Hao Kuo, Assoc Prof Modifications and dynamics of chromatin; transcriptional regulation; proteomic interactions involving posttranslational modifications; tumor suppressor protein p53. Biochemistry and Molecular Biology
John LaPres  John J. LaPres, Assoc Prof Toxicology of transition metals and environmental pollutants; The role of hypoxia signaling in metal-induced toxicity, development, and cancer. Biochemistry and Molecular Biology
Keith Latham
Keith Latham, Prof My research is devoted to understanding the molecular mechanisms that regulate early mammalian embryogenesis, and how disruptions in early developmental events can lead to disease later in life.  Animal Science and Obstetrics Gynecology and Reproductive Biology
Gina M. Leinninger Gina M. Leinninger, Prof The incidence of obesity-linked diabetes (type-2 diabetes) is increasing worldwide and has accordingly been termed “the diabesity epidemic.”  Despite the prevalence of overweight and obesity there are no truly effective pharmacological treatments or cures.  Additionally, homeostatic systems regulated by the brain oppose sustained weight loss.  Thus, understanding how the brain regulates energy balance and weight is crucial to developing better therapeutics for treatment and prevention of obesity and obesity-linked disease. Physiology
Frederic Manfredsson
Frederic Manfredsson, Asst Prof Engineering of novel viral vectors for the use in the nervous system and beyond. This involves the rational design of new expression cassettes as well as the engineering of novel viral capsids.The use viral vectors to study the molecular etiology involved in neurodegenerative disorders such as Parkinson’s disease. Translational Science and Molecular Medicine
Linda Mansfield
Linda Mansfield, Prof Enteric bacterial pathogen Campylobacter jejuni-- the mechanisms that initiate autoimmunity and the diversity of hosts Large Animal Clinical Sciences and Micrology and Molecular Genetics
Laura McCabe
Laura McCabe, Prof Focuses on understanding the mechanisms regulating bone cell (osteoblast) differentiation and bone formation. Physiology
Justin McCormick
Justin McCormick, Assoc Dean Understanding genetic changes at the molecular level that are involved in the transformation of normal human cells into cancer cells. Osteopathic Medicine
Katheryn Meek
Katheryn Meek, Prof How DNA double strand breaks (DSBs) are repaired-- focused on serine/theroine protein kinase Pathobiology and Diagnostic Investigation Microbiology and Molecular Genetics
Richard Miksicek
Richard Miksicek, Assoc Prof breast cancer and normal mammary gland biology, with an emphasis on the role of steroid hormones and their receptors in cell growth and differentiation. Physiology
Kyle Miller
Kyle Miller, Assoc Prof “How do axons grow?”. We address this problem by analyzing the biogenesis, transport, and degradation of organelles and cytoskeletal elements in neurons using time-lapse microscopy, mathematical modeling, gene disruption and biophysical analysis. Integrative Biology
Beronda Montgomery  Beronda L. Montgomery, Assoc Prof Molecular basis of organ-specific phytochrome responses in higher plants; light-regulated development in cyanobacteria. Biochemistry and Molecular Biology
Karl Olson
Karl Olson, Assoc Prof Regulation of pancreatic ß-cell growth, differentiation, and physiology. Isolation and characterization of pancreatic precursor cells. Physiology
Katherine Osteryoung
Katherine Osteryoung, Prof Elucidating the mechanisms powering plastid division in plant cells. Plant Biology
Narayanan Parameswaran
Narayanan Parameswaran, Assoc Prof Understand the cellular and molecular mechanisms of inflammation in disease processes such as sepsis and inflammatory bowel disease. The understanding how changes in gut microbiota modulates gut inflammation and how it links to different organs.
 
Physiology

k. racicot

Karen Racicot, Understand the regulation of inflammation and innate immune cells at the maternal-fetal interface and determine how they affect fetal development and maternal health. Obstetrics Gynecology and Reproductive Biology

A Ralston

Amy Ralston, Prof Making and Using Stem Cells - Lessons from the Mouse Embryo Biochemistry and Molecular Biology
John Risinger
John Risinger, Prof The underlying molecular defects that lead to endometrial and ovarian cancer. Our laboratory focuses on several aspects of gynecologic cancer. Obstetrics Gynecology and Reproductive Biology
Cheryl Rockwell
Cheryl Rockwell, Asst Prof Mechanisms that regulate immune cell activation and polarization and the downstream effects of this on immune function. Particularly interested in how these processes are disrupted in autoimmune disease and allergy. In addition, we also investigate how xenobiotics modulate immune cell function and the effect of this on overall immunity. Pharmacology and Toxicology
Robert Roth
Robert Roth, Prof Inflammation as a determinant of susceptibility to the toxic effects of drugs and other chemical agents. Pharmacology and Toxicology
Brian Schutte
Brian Schutte, Assoc Prof Genes and pathways that are essential for craniofacial development and studies that show how genetic variation in IRF6 contributes to isolated cleft lip and palate Microbiology and Molecular Genetics
 
Richard Schwartz
Richard Schwartz, Assoc Dean Impact of a high fat diet on mammary tumorigenesis, the role of inflammatory and immune processes in mammary tumorigenesis, and the roles of estrogen and progesterone in regulating the expression of proinflammatory genes in mammary epithelial cells and inflammatory processes in the mammary gland. Microbiology and Molecular Genetics
Yair Shachar-Hill
Yair Shachar-Hill, Prof Our group studies metabolism and transport in plant systems. We are very interested in analyzing and modeling the fluxes through metabolic networks in developing seeds, arbuscular mycorrhizas, and other cells and tissues.  Plant Biology

Ashley Shade, Asst Prof Ecological and evolutionary dynamics of microorganisms within their communities Microbiology and Molecular Genetics
Shin-Han Shiu
Shin-Han Shiu, Assoc Prof Understand the molecular basis of adaptations via studying the molecular evolutionary patterns of plant genes. In the near term, we are particularly interested in understanding the evolutionary history and functional differentiation between duplicate genes. Plant Biology
George Smith
George Smith, Prof Understanding the local regulation of ovulation and corpus luteum development with major emphasis on the regulation and regulatory role of extra cellular matrix degrading proteinases and their inhibitors in follicle rupture and the periovulatory follicle/luteal transition. Animal Science
Dana Spence
Dana Spence, Prof Solving biological problems at the molecular level with the help of novel biotechnology method development Chemsitry
William Spielman
William Spielman, Prof Understanding the regulation and dysregulation of salt and water homeostasis. Physiology
Jose Teixeira
Jose Teixeira, Prof Reproductive tract and gonadal developmental with major research interests focused on four complementary studies directly related to women's health and reproduction. Obstetrics aGynecology and Reproductive Biology
Suzanne Thiem
Suzanne Thiem, Assoc Prof Molecular biology and genetics of insect baculoviruses and understanding the molecular basis of baculovirus pathogenesis Entomology and Microbiology and Molecular Genetics
Michael Thomashow
Michael Thomashow, Prof Function and regulation of a family of cold-regulated Arabidopsis genes designated COR Microbiology and Molecular Genetics
Frances Trail
Frances Trail, Prof Understand the entire life cycle of Fusarium graminearum in the field, focusing on Ascospore discharge, Perithecium Development, and Mycotoxins. Plant Biology
Steven Triezenberg
Steven Triezenberg, Adjunct Prof Mechanisms of gene regulation in eukaryotes; transcriptional activation; herpes simplex virus; viral and cellular regulatory proteins; transcriptional adaptors and histone acetylation in plants. Van Andel Research Institute
Bruce Uhal
Bruce Uhal, Prof Elucidate the mechanisms that control apoptosis of lung epithelial cells. Physiology
Steven van Nocker
Steven van Nocker, Prof Genetic and epigenetic mechanisms in plant development Horticulture

Irving Vega

Irving Vega, Assoc Prof Understanding of how neurons respond to the presence of pathological tau in different brain regions that are susceptible or resistant to tau-mediated neurodegeneration.   Translational Science and Molecular Medicine

Almudena Veiga-Lopez

Almudena Veiga-Lopez, Prof Our laboratory focuses on understanding the fetal origins of adult reproductive and metabolic disorders. The lab is interested how environmental exposures (endocrine disruptors) during prenatal life can induce adaptative mechanisms in the developing organism leading up to pathophysiological consequences during postnatal life. We use in vivo approaches to characterize the pathophysiological outcomes and in vitro approaches (cellular and molecular) to understand the mechanisms and pathways by which the pathological outcomes occur. Animal Science
Claire Vielle  Claire Vieille, Assoc Prof Microbial metabolic engineering; determinants of hyperthermophilic protein stability; protein engineering; electricity-driven cofactor recycling. Biochemistry and Molecular Biology
Kevin D. Walker  Kevin D. Walker, Assoc Prof Elucidation of biosynthetic pathways of plant-derived products for use (and potential use) as pharmaceuticals, neutraceuticals, and allelochemicals, utilizing an array of methodologies grounded in bioorganic chemistry, organic synthesis, enzymology, molecular genetics, molecular biology, and natural products isolation and characterization (i.e., metabolomics). Biochemistry and Molecular Biology
Jonathan Walton
Jonathan Walton, Prof Ecological and biotechnological aspects of both fungal natural products and fungal degradative enzymes. Plant Reserach Laboratory, Plant Biology
Donna Wang
Donna Wang, Prof Cardiovascular medicine, neurobiological science, nanotechnology, and drug discovery. Medicine
Hongbing Wang
Hongbing Wang, Assoc Prof The overall objective of Xiao´s laboratory is to study the regulatory mechanisms and signal transduction pathways pertaining to the RNA polymerase II machinery and modulators of transcription such as estrogen receptors and transcription cofactors that are involved in tumorigenesis. Physiology and Neuroscience
John L. Wang  John L. Wang, Prof Carbohydrate recognition; analysis of carbohydrate-binding proteins in the cell nucleus; nuclear processing and export of mRNA. Biochemistry and Molecular Biology
Christopher Waters
Christopher Waters, Assoc Prof Role of chemical signaling in bacterial biofilm formation and develops new approaches to inhibits biofilms. Microbiology and Molecular Genetics
Daivd Weliky
David Weliky, Prof Nuclear magnetic resonance and other biochemical and biophysical methods to understand the structure and function of membrane fusion proteins of viruses. Chemistry
Robert Wiseman
Robert Wiseman, Prof Cellular adaptation and altered gene expression in skeletal muscle and heart
Regulation of energetics and calcium homeostasis in skeletal muscle.
Physiology
Hua Xiao
Hua Xiao, Assoc Prof Regulatory mechanisms and signal transduction pathways pertaining to the RNA polymerase II machinery and modulators of transcription such as estrogen receptors and transcription cofactors that are involved in tumorigenesis. Physiology and Pathology
Honggao Yan Honggao Yan, Prof Protein structure, function, and dynamics; protein engineering; multidimensional multinuclear NMR; 6-hydroxymethyl-7, 8-dihydropteroate pyrophosphokinase; shikimate kinase; cytosine deaminase. Biochemistry and Molecular Biology
Chengfeng Yang
Chengfeng Yang, Assoc Prof The research in my laboratory investigates the roles of non-coding RNAs in cancer and the environmental toxicants’ effect on development. Physiology and Veterinary Medicine
Kefei Yu
Kefei Yu, Assoc Prof DNA recombination and DNA repair in immune cells in association with antigen receptor gene diversification Microbiology and Molecular Genetics
Timothy R. Zacharewski Timothy R. Zacharewski, Prof Toxicogenomics; receptor-mediated toxicology; endocrine disruption; expression profiling; ligand-induced protein structure. Biochemistry and Molecular Biology
Yong-Hui Zheng
Yong-Hui Zheng, Assoc Prof Etrovirus-host interactions using HIV-1, a human retrovirus that causes AIDSs and the natural host factors that have the ability to inhibit retrovirus replication. Microbiology and Molecular Genetics